Pipeline of phase-defined complete sequencing for the HLA genes


  • Completed
  • DICP Tool Prototype Trial for Integrated Database Analysis
  • Projects funded in FY 2014

Name and affiliation of Research Director


Visiting Researcher, Division of Human Genetics, National Institute of Genetics

Outline of R&D

The human leukocyte antigen (HLA) has been associated with more than 100 different diseases, mostly autoimmune diseases. In addition specific alleles of HLA genes are strongly associated with drug hypersensitivity induced by specific drugs. Therefore, the HLA typing is one of the important tools as clinical application, medical research, and population genetics. I would like to start the project to establish phase-defined sequencing pipeline which was optimized for HLA gene sequences using NGS data, and has been available as web-based analysis tool. The pipeline will be greatly advantageous for clinical (diagnostic) application that requires a user-friendly protocol, with high throughput and accuracy.

Main database(s) subject to research and development

Period of research and development

September 2014 to February 2015

DocumentsOnly in Japanese

Presentation documents


EvaluationOnly in Japanese

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