Development of pdbBAM, comprehensive mapping of PDBj protein sequences on human genome

Category

  • Completed
  • DICP Tool Prototype Trial for Integrated Database Analysis
  • Projects funded in FY 2014

Name and affiliation of Research Director

SHIROTA Matsuyuki

Assistant Professor, Graduate School of Medicine, Tohoku University

Outline of R&D

In this trial, I will convert the amino acid sequences of the protein structures in PDBj to the sponding mRNA sequences, map them onto human reference genome and generate pdbBAM, which integrates the genomic positions and mutations of all of the PDBj structures in BAM format. This tool aims to enable the scientists to grasp the availability of 3D-structural information in each genomic position by browsing high-throughput sequencing results. pdbBAM will bridge the gap between personal genomics and structural biology and help to accelerate the study of personalized medicine and drug discovery.

Main database(s) subject to research and development

Period of research and development

September 2014 to February 2015

DocumentsOnly in Japanese

Presentation documents

Reports

EvaluationOnly in Japanese

Inquiries & opinions

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