Development of pdbBAM, comprehensive mapping of PDBj protein sequences on human genome
Category
- Completed
- DICP Tool Prototype Trial for Integrated Database Analysis
- Projects funded in FY 2014
Name and affiliation of Research Director
SHIROTA Matsuyuki
Assistant Professor, Graduate School of Medicine, Tohoku University
Outline of R&D
In this trial, I will convert the amino acid sequences of the protein structures in PDBj to the sponding mRNA sequences, map them onto human reference genome and generate pdbBAM, which integrates the genomic positions and mutations of all of the PDBj structures in BAM format. This tool aims to enable the scientists to grasp the availability of 3D-structural information in each genomic position by browsing high-throughput sequencing results. pdbBAM will bridge the gap between personal genomics and structural biology and help to accelerate the study of personalized medicine and drug discovery.
Main database(s) subject to research and development
Period of research and development
September 2014 to February 2015
