JoGo-Next: Construction of a Human Haplotype Database for International Standards and AI Utilization
Category
- In progress
- Database Integration Coordination Program (DICP)
- Projects funded in FY 2026-Fostering
Name and affiliation of Research Director
NAGASAKI Masao
Professor, Medical Institute of Bioregulation, Kyushu University
Outline of R&D
We will further expand the “JoGo” database of human gene haplotypes based on the ACTG hierarchical nomenclature. Specifically, we will: (1) add new haplotype dictionaries for non-coding genes and regulatory regions; (2) incorporate sequence structures of medically relevant multigene clusters, including duplicate regions and copy number variations, using in-house and international telomere-to-telomere (T2T) resources; (3) enhance the dictionaries by increasing the number of reference individuals; (4) develop methods to estimate haplotypes from short-read whole-genome sequencing and release population-level haplotype statistics in Japan and worldwide; (5) semi-automate data updating, quality control, and annotation using AI agents; and (6) strengthen international collaboration. Through these efforts, we aim to establish JoGo-Next as the international de facto standard for haplotype databases and to advance research in genome science and genetic diseases.
Main database(s) subject to research and development
Period of research and development
Apr 2026 to Mar 2029
Grant Number
JPMJND2601
